PRISMA - Pulmonary Rehabilitation: a response for patients with COPD in an InduStrialized environment and its implication on lung MicrobiotA
Alda Marques
Ana M. Sousa; Ana C. Sousa
Project type
Projet OHM
OHM(s) involved
  • OHMI Estarreja
Biologie, Éco-épidémiologie, Médecine, Santé publique
PRISMA capitalizes on MicroRESPIRA, which found high abundance of bacteria, allergic and pathogenic agents for the human respiratory tract above the admissible values set by the National Legislation in the homes of patients with chronic obstructive pulmonary disease. Therefore, these people are at higher risk of having acute exacerbations, which causes severe individual, social and economic impacts. However, little has been done to improve patients’ awareness about the impact their home environment might have in their disease and quality of life. Pulmonary rehabilitation (PR) is an evidence-based intervention known to improve patients’ education, reduce symptoms, exacerbations, hospital admissions and quality of life however, it is highly inaccessible. PRISMA will overcome this barrier. It will also enhance our understanding of the mechanisms behind the effectiveness of PR by exploring the modulation of lung microbiota, since acute exacerbations might be caused by individual’s microbiota, however, this is still poorly understood.


2019-05-03 15:24:57
2019-02-21 10:13:15
Alda Marques is currently a senior lecturer at School of Health Sciences (ESSUA) and a research member of the Institute for Biomedicine (iBiMED), University of Aveiro, Portugal. Since 2009, coordinates the LAB3R-Respiratory Research and Rehabilitation Laboratory at ESSUA. Marques is currently an active member of the European Respiratory Society, American Association of Respiratory Care, International Lung Sound Association, Portuguese Society of Pneumology and is the President of the cardiorespiratory group of the Portuguese Physiotherapy Association. Her research interests are by working with multidisciplinary teams, to: i) explore the effectiveness and different models of delivery PR; ii) improve patients with respiratory diseases and their families management and iii) develop and implement new measures or core outcome sets to be used clinically.
Marques has more than 100 publications in peer-reviewed journals, 3 published books and 8 book chapters in respiratory diseases. She has been principal investigator of 12 funded research projects (FCT/FCG/COMPETE2020) related with respiratory disease or dementia management, 3 of them ongoing. She has been also a member of the research team of 5 other funded research projects, one an international multicenter trial. Marques has vast experience in supervising Post-docs, PhDs and Master students. The results from these studies have and will continue to contribute to a further development of the non-pharmacological management of patients with chronic diseases and their families. Marques has received 18 awards for her work, one of which the first prize for the best work conducted in “Rehabilitation & Chronic Care”, awarded by the European Respiratory Society.


Ana C.
Ana C. Sousa (PhD) is a postdoctoral fellow of OHMi Estarreja-OHM Bassin Minier de Provence and member of the LabEx. Sousa graduated in biology from the University of Aveiro in 2001, and completed her PhD in September 2009 at the same institution. Sousa’s work focus on environmental contaminants, particularly endocrine disruptors, and their impact in wildlife and human health. Sousa has worked and continues to collaborate with several foreign institutions including the University of Coruña (Spain), the Swiss Federal Institute for Environmental Science and Technology (EAWAG), Switzerland; the National Institute for Environmental Studies (NIES), Japan; the Center for Marine Environmental Studies (CMES), Japan and the Colorado School of Mines, USA.
During her career, Sousa has successfully obtained grants from national and international competitive applications (e.g. FCT, Gulbenkian Foundation, and the Japanese government). Sousa is the PI of RESPIRA and microRESPIRA financed by...
Ana M.
Ana Sousa (PhD) is an Invited Assistant Professor at the Department of Medical Sciences at the University of Aveiro and a Principal Investigator at the Institute of Biomedicine (iBiMED) in the same university. She completed her PhD in 2008 at the Faculty of Sciences (University of Lisbon) and did a Postdoc at the Gulbenkian Institute of Science.
Her work focus on understanding what shapes the microbiota, how it changes over time and on the consequences of these changes to the host. She collaborates with several researchers with complementary expertise, such as a physiotherapist specialist at chronic respiratory diseases at the iBiMED (Alda Marques), an immunologist at the Chronic Diseases Research Centre (Portugal), a quantitative geneticist at the Gulbenkian Institute of Science and a theoretical physicist at the University of Cologne (Germany). These collaborations strengthen the multidisciplinary approach taken by Ana Sousa in her research. During her career, she has...
Carla V. Silva (MD) is the pneumologist from the Centro Hospitalar do Baixo Vouga (CHBV)in charge of consultations on the units of Estarreja and Águeda. Silva graduated in medicine in 2002 from the University of Coimbra, completed her general internship in 2004 at the Hospital Infante D. Pedro, CHBV, and her complementary internship in pneumology at the university hospital of Coimbra, in 2010 from where she acquired experience in internal medicine, general pneumology, physiopathology and pulmonary rehabilitation, respiratory endoscopy, oncology, intensive medicine, alergology, primary care, thoracic surgery, imagiology and infectiology. In consultations, Silva works with people with respiratory failure, sleep pathologies, cystic fibrosis, COPD, pre-tranplantation, and smoking cessation consultations. Silva has 42 published abstracts in national and international journals, 13 national and 2 international oral communications, and 21 national and 4 international posters in...
Sara Miranda (PT), is a research fellow at iBiMED – Institute for Research in Biomedicine and at ESSUA – School of Health Sciences, University of Aveiro, Portugal. Miranda graduated in physiotherapy from the University of Aveiro in 2016 and completed her specialization course in respiratory physiotherapy for adults, in the same institution in 2017. Miranda was a research fellow for a project entitled GENIAL – genetic and clinical markers in the trajectory of COPD” (PTDC/DTP-PIC/2284/2014), fun“ded by the national foundation for science and technology and is currently working in a multicentric project with University of Aveiro and University of Toronto, entitled “Randomized controlled trial of balance training for fall reduction in individuals with COPD” (ref.363312), funded by the Canadian Institutes of Health Research. In 2017, Miranda has conducted 2 seminars directed for graduation students from ESSUA about the evaluation and intervention of the physiotherapist in...
Célia Freitas (PhD) is an Adjunct Professor at the School of Health Sciences at the University of Aveiro and a collaborator researcher at the Center for Health Technology and Services Research (CINTESIS) at the University of Porto. She completed her PhD in Didactics and Education in 2012 at the department of Education and Psychology (University of Aveiro).
During her career as a nurse (up to 2013), she has been dedicated to the health promotion and developed several projects in the community, namely, the continuous care at home integrated in the National Network of Continuous Care (RNCCI), whose main mission is to provide health care and social support to dependents. She also focuses her work on health literacy and chronic disease management, like respiratory, diabetes, cancer and she consider this a challenge to improve the quality of life and health outcomes in people with chronic diseases, and develop of self-management behaviors.
Since 2012 she has published one paper in...